Avascular Necrosis of the Femoral Head in Patients with Hemoglobinopathies: a Case Series and Review of the Literature
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چکیده
Osteonecrosis or avascular necrosis (AVN) is a pathologic process that results from a critical decrease of blood supply to the bone and elevated intraosseous pressure [1]. While the pathogenic process is not clear, it is believed that osteonecrosis is the final common pathway of traumatic and non-traumatic insults and that it impairs blood circulation to the femoral head. Subsequently, interruption of blood flow to the femoral head leads to the death of bone marrow and osteocytes and usually causes the collapse of the necrotic segment [1].
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